diff --git a/profiles/default/package.keywords/depends b/profiles/default/package.keywords/depends
index 0d9f2f355..7dd9ad4ed 100644
--- a/profiles/default/package.keywords/depends
+++ b/profiles/default/package.keywords/depends
@@ -960,7 +960,7 @@ net-vpn/wireguard-tools amd64
 ~sci-calculators/gonvert-0.2.39 amd64
 ~sci-calculators/grpn-1.4.0 amd64
 ~sci-calculators/qalculate-gtk-3.2.0 amd64
-~sci-chemistry/pymol-2.3.0 amd64
+~sci-chemistry/pymol-2.4.0 amd64
 ~sci-chemistry/pymol-plugins-bni-tools-0.27 amd64
 ~sci-chemistry/pymol-plugins-dssp-110430 amd64
 ~sci-chemistry/pymol-plugins-emovie-1.0.4 amd64